Abstract
Purpose of the Review: The purpose of this narrative review was to compare branded and generic medicines used in general medicine, with special focus on hospital management practices, prescribing behavior of healthcare professionals, and economic impact on patients and healthcare systems.
Findings: Most studies showed that generic medicines are therapeutically equivalent to branded medicines in terms of safety and effectiveness. Despite this, many doctors still prefer branded drugs due to habit, confidence in brands, influence from pharmaceutical representatives, and patient expectations. Pharmacists generally showed greater trust in generic medicines and stronger support for generic substitution. Generic medicines often reduce drug costs, but total healthcare costs do not always decrease because of additional doctor visits, hospital admissions, or treatment changes. Patient beliefs and poor awareness sometimes reduce acceptance of generics, although government supply programs showed good outcomes at lower cost.
Inclusion Criteria: Studies published in English that compared branded and generic medicines, discussed prescribing behavior, hospital management or substitution policies, and reported clinical or economic outcomes in general medicine were included.
Exclusion Criteria: Editorials without data, conference abstracts, non-English articles, and studies not related to general medicine practice were excluded.
Keywords
References
Kumar, R., Bajaj, J. K., Sood, M., Grewal, N., & Jassal, B. (2016). To study prescription behavior of physician in regard to brand and generic name. International Journal of Basic & Clinical Pharmacology, 5(4), 1327–1331.
Straka, R. J., Keohane, D. J., & Liu, L. Z. (2017). Potential clinical and economic impact of switching branded medications to generics. American Journal of Therapeutics, 24(3), e278–e289.
Hazra, P., & Padma, L. (n.d.). Audit of prescriptions from the department of general medicine based on the WHO core prescribing indicators at Sapthagiri Hospital, Bangalore.
Alghasham, A. A. (2009). Generic drug prescribing in central Saudi Arabia: Perceptions and attitudes of physicians. Annals of Saudi Medicine, 29(1), 24–29.
Gothe, H., Schall, I., Saverno, K., Mitrovic, M., Luzak, A., Brixner, D., & Siebert, U. (2015). The impact of generic substitution on health and economic outcomes: A systematic review. Applied Health Economics and Health Policy, 13(Suppl. 1), 21–33.
George, T. R. (n.d.). Generic drugs: Physician prescribing practices for brand-name and generic medications (Doctoral dissertation, Walden University).
Manzoli, L., Flacco, M. E., Boccia, S., D’Andrea, E., Panic, N., Marzuillo, C., Siliquini, R., Ricciardi, W., Villari, P., & Ioannidis, J. P. A. (2016). Generic versus brand-name drugs used in cardiovascular diseases. European Journal of Epidemiology, 31(4), 351–368.
Ordóñez, K., Feinstein, M. M., Reyes, S., Hernández-Gómez, C., Pallares, C., & Villegas, M. V. (2019). Clinical and economic impact of generic versus brand name meropenem use in an intensive care unit in Colombia. The Brazilian Journal of Infectious Diseases, 23(4), 237–245.
Rinaldi, A., Bullo, A., & Schulz, P. J. (2025). Patients’ requests and physicians’ prescribing behavior. Patient Education and Counseling, 108747.
Mahato, T. K., & Raulji, D. (2021). Present scenario of generic medicines in India: A comparative study. World Journal of Biology Pharmacy and Health Sciences, 7(2), 53–59.
Das, A., Mukhopadhyay, R., Kumar, S. E., Gopinath, P. L., & Vibha Manu, M. D. (2025). A cross-sectional study on behavioral health, usage of prescription patterns, and cost analysis of antidepressant medications in alcohol dependence syndrome at a tertiary care hospital in Bangalore, Karnataka, India. IP Indian Journal of Neurosciences, 11(3), 178–186.
Ryynänen, S. (2020). Patient complaints: Patients’ and physicians’ interaction in handling complex requests of care. Journal of Patient Experience, 7(4), 464–467.
Erçalışkan, A., Seyhan Erdoğan, D., & Eşkazan, A. E. (2021). Current evidence on the efficacy and safety of generic imatinib in CML and the impact of generics on health care costs. Blood Advances, 5(17), 3344–3353.
Toverud, E. L., Hartmann, K., & Håkonsen, H. (2015). A systematic review of physicians’ and pharmacists’ perspectives on generic drug use: What are the global challenges? Applied Health Economics and Health Policy, 13(Suppl. 1), 35–45.
Colgan, S., Faasse, K., Martin, L. R., Stephens, M. H., Grey, A., & Petrie, K. J. (2015). Perceptions of generic medication in the general population, doctors and pharmacists: A systematic review. BMJ Open, 5(12), e008915.
Das, M., Choudhury, S., Maity, S., Hazra, A., Pradhan, T., Pal, A., & Roy, R. K. (2017). Generic versus branded medicines: An observational study among patients with chronic diseases attending a public hospital outpatient department. Journal of Natural Science, Biology and Medicine, 8(1), 26–31.
Priyadarsini, R., Maheswari, Y. N., Prabha, M. L., & Ramya, J. E. (2023). A comparative study on perception and use of generic drugs between public and private health practitioners. Journal of Family Medicine and Primary Care, 12(12), 3222–3227.
AlOmeir, O., Almuqbil, M., Alsawadi, A. H., Genedy, A. M., Almutairi, A. F., Alaydaa, H. T., Alanazi, S. A., Alabdan, N., Alshakrah, M., Gilkaramenthi, R., & Asdaq, S. M. B. (2024). An exploration of factors influencing the selection of generic and innovator medicines in Saudi Arabia using an observational cross-sectional study. Saudi Pharmaceutical Journal, 32(4), 102021.
Madan, S., & Juyal, S. A. (2024). Influence of medical practitioners’ attitude on the prescription behaviour for generic medicines. Journal of Health Management, 26(1), 154–163.
Socal, M. P., Cordeiro, T., Anderson, G. F., & Bai, G. (2022). Estimating savings opportunities from therapeutic substitutions of high-cost generic medications. JAMA Network Open, 5(11), e2239868.
Dunne, S., Shannon, B., Hannigan,A., Dunne, C., & Cullen, W. (2014). Physician and pharmacist perceptions of generic medicines: What they think and how they differ. Health Policy, 116(2–3), 214–223.
Auta, A., Bala, E. T., & Shalkur, D. (2013). Generic medicine substitution: A cross-sectional survey of the perception of pharmacists in north-central, Nigeria. Medical Principles and Practice, 23(1), 53–58.
Čatić, T., Avdagić, L., & Martinović, I. (2017). Knowledge and attitudes of physicians and pharmacists towards the use of generic medicines in Bosnia and Herzegovina. Medicinski Glasnik, 14(1), 25–32.
Lewandowski, M., Religioni, U., Barańska, A., Wdowiak, K., Kobayashi, A., Borowska, M. W., Czech, M., Wierzbiński, P., Śliż, D., Plagens-Rotman, K., & Merks, P. (2025). Analysis of the physicians’ perception of original and generic drugs in Poland. Arterial Hypertension, 29, 115–122.
Azam, A., Hamza, M. A., Sarwat, R., Latif Akhter, A. A., Zahra, B. B., Awan, B., Ahmed, A. (2025). Assessment of physicians’ and pharmacists’ knowledge, attitudes, perceptions, and barriers concerning generic medicine in Pakistan: A cross-sectional study. Journal of Generic Medicines, 21(4), 156–166.
Yeung, K., & Ulloa, E. (2022). Incentivizing prescription drug switching to reduce patient and health plan spending: A microsimulation model. Value in Health, 25(3), 427–434.
Lavtepatil, S., & Ghosh, S. (2022). Improving access to medicines by popularising generics: A study of India's People's Medicines scheme in two districts of Maharashtra. BMC Health Services Research, 22(1), 643.
Chong, C. P., March, G., Clark, A., Gilbert, A., Hassali, M. A., & Bahari, M. B. (2011). A nationwide study on generic medicines substitution practices of Australian community pharmacists and patient acceptance. Health Policy, 99(2), 139–148.
Lavtepatil, S., & Ghosh, S. (n.d.). Prescribing trends—Branded versus unbranded generics and rational use of medicine at public health facilities in Maharashtra.
Rana, P., & Gupta, R. (2025). Generics versus branded generics: A case of confusion. Indian Journal of Community and Family Medicine, 11(1), 4–7.